Piero di Cosimo - Perseus Frees Andromeda
The paintings of Cosimo are filled with allegorical and mythological imagery. One of the more striking examples of this can be found in this scene from Greek Mythos. Learn more about this painting here. Another example of this scene can be found here.
More works by the artist can be found here.
And most people are probably familiar with this scene as it was shown in a certain Ray Harryhausen film.